Bradforth Research Group
Home People Papers Science Links Intranet

Konstantin Kudinov

Scintillating Nanoparticles for Tumor Radiation Therapy
Konstantin Kudinov and Sathvik Shastry

Sathvik Shastry

Scintillating nanoparticles generate UV light (or scintillation) while they are irradiated by X-ray/gamma radiation (often used in cancer radiotherapy). The emission spectrum of these particles overlap the absorption of the many porphyrin photosensitizing agents that are used in photodynamic therapy because they create singlet oxygen on excitation. When we conjugate porphyrins to doped lanthanum fluoride nanoparticles, we observe energy transfer between the nanoparticles and porphyrins. Thus, our project aims to show that by exciting nanoparticles that are taken up by tumor cells with gamma radiation we may trigger singlet oxygen generation and thus tumor cell killing. Because radiation is used, this type of therapy can be effective in the parts of the body where it is difficult to get light to penetrate.

The ability to convert absorbed gamma radiation into self-excitation of NP is the key to making the project work. One of the major goals of this research is to measure the conversion efficiency between X-ray radiation and NP excitation. The amount of visible light emitted by NP while they are being irradiated by gamma radiation is this measure of conversion efficiency.

LaF3:Ce conjugate